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KMID : 1137020070180040284
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Journal of Gynecologic Oncology
2007 Volume.18 No. 4 p.284 ~ p.288
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Expression of c-Met in ovarian epithelial tumor
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Kim Bo-Seop
Park Il-Soo
Lee Yoon-Soon
Koo Tae-Bon
Park Tae-In
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Abstract
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Objective: This study was performed to evaluate the expression of c-Met in epithelial ovarian carcinoma.
Methods: Paraffin-embedded tissues from 50 epithelial ovarian adenocarcinomas were stained immunohistochemically for c-Met expression. The expression of c-Met was correlated with clinicopathologic parameters including, histologic type, tumor size, and tumor stage.
Results: c-Met expression was found in 29 cases (58%) among 50 ovarian cancers. In clinicopathologic study, c-Met expression of epithelial ovarian carcinomas did not show the correlation with clinicopathologic parameters such as histologic type, tumor size and stage.
Conclusion: c-Met expression might be a potential prognostic marker for patients with advanced stage epithelial ovarian cancers. However, larger population-based studies should be performed to determine the prognostic potential of c-Met expression in advanced ovarian carcinoma.
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KEYWORD
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Epithelial ovarian cancer, Prognosis
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